Abstract
Background: Serum amyloid A (SAA1) is an apolipoprotein that maintains glucose and lipid homeostasis. Its polymorphisms are associated with risks of myocardial infarction and coronary artery disease (CAD). Methods: However, little is known about the associations of these polymorphisms with susceptibility to osteoporosis, which we evaluated in this hospital-based case–control study involving 300 osteoporosis patients and 350 controls. Three single-nucleotide polymorphisms (SNPs) (rs183978373, rs12218, and rs10832915) were genotyped using MALDI TOF MS. Results: There were no differences in the rs183978373 and rs12218 polymorphisms between the osteoporosis group and controls. The SAA1 gene rs10832915 polymorphism increased the risk of osteoporosis in our Chinese population. The genotypes of the rs10832915 polymorphism were not significantly associated with clinical parameters (age, body mass index (BMI), high- and low-density lipoprotein (LDL), total cholesterol (TC), and T-score). Haplotype analysis revealed that the ATT haplotype had a significant correlation with a decreased risk of osteoporosis. Conclusion: In conclusion, the SAA1 rs10832915 polymorphism and its haplotypes are associated with osteoporosis, but this finding should be confirmed in large well-designed studies.
Highlights
Osteoporosis is the most common bone disease and is characterized by a reduction in bone mineral density (BMD), a deterioration of the bone tissue microarchitecture, and an increased risk of fractures [1]
Rs12218 was under linkage disequilibrium with two other single-nucleotide polymorphism (SNP) that were located in the intron region of serum amyloid A (SAA1) gene (Figure 3)
Significant differences between the cases and the controls were found in T-scores and Z-scores, but not in body mass index (BMI), high-density lipoprotein (HDL), low-density lipoprotein (LDL), or total cholesterol (TC)
Summary
Osteoporosis is the most common bone disease and is characterized by a reduction in bone mineral density (BMD), a deterioration of the bone tissue microarchitecture, and an increased risk of fractures [1]. A genetic study revealed that osteoporosis has a major risk of low BMD and is controlled genetically [5]. The higher HDL-C level of high-SAA1 patients is associated with increased all-cause and cardiovascular mortality rates [7]. The incidence of CAD including a high coronary artery calcium score (≥100), obstructive CAD, and multivessel disease is significantly higher in lower BMD subjects, including those with osteopenia and osteoporosis [9]. Its polymorphisms are associated with risks of myocardial infarction and coronary artery disease (CAD). The SAA1 gene rs10832915 polymorphism increased the risk of osteoporosis in our Chinese population. The genotypes of the rs10832915 polymorphism were not significantly associated with clinical parameters (age, body mass index (BMI), high- and low-density lipoprotein (LDL), total cholesterol (TC), and T-score). Conclusion: In conclusion, the SAA1 rs10832915 polymorphism and its haplotypes are associated with osteoporosis, but this finding should be confirmed in large well-designed studies
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