SA45 - AFFECTIVE TEMPERAMENT AND DEPRESSIVE SYMPTOMS IN OBESE INDIVIDUALS IN THE CONTEXT OF SEROTONERGIC TRANSCRIPTIONAL GENE POLYMORPHISMS

Abstract

Background Patients with obesity experience many psychological burdens. Some of them result directly from the load that jets excessive weight. Nevertheless, it seems that the susceptibility of obese people to accompanying mental disorders can be ingested not only by the environment, but also genetically. The aim of this work was to determine the correlation of the genetic aspects of serotoninergic (SERT, 5-HT2A) transmission with the severity of depressive symptoms and the affective temperament profile in subjects with simple obesity. Methods The study included 506 patients with simple obesity who were excluded secondary causes of obesity and significant mental illness. Clinical, psychological and genetic analyzes were performed. To assess the severity of depressive symptoms, Beck Depression Inventory and the Hamilton Depression Scale were used. Affective temperament was assessed using the TEMPS-A questionnaire. Polymorphism of serotonin transporter (SERT 44-bp insertion/deletion) and serotonin receptor 2 A type (1438 G/A) were evaluated as potential genetic markers of psychological factors. Results The long allele of SERT gene was associated with significantly higher BMI and more pronounced depressive, cyclothymic and hyperthymic dimensions of affective temperament. Interestingly, these subjects obtained the lowest scores of both scales, which measured the severity of depressive symptoms. Adenine homozygotes in examined 5-HT2A polymorphism were characterized by higher BMI and more pronounced anxious and, in particular, hyperthymic dimension of temperament. Carriers of particular polymorphisms in this gene did not differ significantly in the clinical scale evaluating the severity of depressive symptoms. Discussion Polymorphisms of both examined genes revealed correlations in affective temperamental dimensions. Acknowledgments in the SERT polymorphism seems to play a more important role in the regulation of reactive depressive symptoms.