Sa2048 Distribution of Transient Receptor Potential Melastatin 2 Channels-Expressing Nerve Fibers in Rat Alimentary Tract and Dorsal Root Ganglion

Abstract

and methods: We included adult patients ≥18 years old with PF and LAS according to Rome III who had completed Hamilton survey. Patients lost in the follow up were eliminated. The study was conducted in a private ambulatory coloproctology center between May 2010 and 2012. Design: Prospective, descriptive and longitudinal study. Symptoms were assessed by medical interview and patients were treated according to the institutional therapeutic algorithm. Response was assessed by Visual Analogue Scale (VAS) every 3 weeks for 6 months. Favorable response was considered when patients reported symptom remission or a decrease ≥ 50% in VAS; unfavorable response was considered when patients reported a decrease ,50% in VAS. Overall response was assessed after 6 months follow up. Anxiety and depression (scores ≥ 11 in each disorder according to Hamilton survey), psychiatric comorbidities at diagnosis, bowel habits and pain characteristics were registered. Statistical Analysis: VCCstat 1.0. Package; 95% CI were estimated; Fisher test. Results: We included 48 patients, eliminated 12 and analyzed 36 patients; 60% (22/36) were male, mean age was 52 years (range 21-83). PF was reported in 8.33% (3/36) and LAS in 92% (33/36) 1. The favorable response rate was 34/36 (94%; 95 CI 81-99). All had complete remission. 2/36 (6%; 95 CI 0.7 18) had unfavorable response. 2. The prevalence of anxiety and depression was 16/36 (44%; 95 CI 28-61) and 10/36 (28%; 95 CI 14-45) respectively. Additionally we examined whether each of these disorders were different in the absence (G1) or presence (G2) of psychiatric co morbidities. No statistically significant relationship was observed between the presence of psychiatric comorbidity and anxiety (p (Fisher) = ns), the depression was statistically more prevalent (43% CI 95 20-70) in G2 (P (Fisher) = 0.00069)). Conclusions: Treatment response was favorable in most patients. One third reported anxiety or depression. This last disorder was more prevalent in the presence of psychiatric comorbidity. These data evidence the impact of pain control in psychiatric symptoms/comorbidities and consequently in patient's quality of life.