Abstract
responses and learning in the water maze. RESULTS: A difference in the microbial alpha diversity was observed between bTBIs (S-BTI and R-TBI) and the sham group. Compared to sham, MLNs from bTBIs had increased Actinomycetales Coriobacteriaceae (sham:4.6% vs bTBI:11.6%) and lower Firmicutes (sham:23% vs bTBI:14%) of the total bacterial load. MLNs collected at 2 weeks in the R-BTI group had higher loads of both the Actinomycetales Coriobacteriaceae and Firmicutes than those of S-TBI. Colonic motility was reduced post STBI and increased post R-TBI. Both S-TBI and R-TBI, compared to sham rats, showed persistent alterations in gait-dynamics, startle and pre-pulse inhibition responses and learning in the water maze that developed fully after the repeated blast. CONCLUSION: bTBI modulates microbial load to intestinal MLNs, alters colonic motility as well as motor, behavior and cognition in rats. Gut function is altered in bTBI and changes in gut function in bTBI may serve to assess the severity of injury following acute or chronic bTBI. Supported by R01DK078676 (MM);VA-RR&D #B5089R (OS).
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
