Abstract
flux. Conclusions: Ethanol alone does not stimulate autophagosome formation due to excessive LC3-II delipidation by Atg4. In contrast, ethanol+ low-dose CR pancreatitis decreases Atg4 and stimulates autophagy. Both ethanol and alcoholic pancreatitis cause lysosomal dysfunction resulting in impaired autophagic flux. The results support our "2-hit" hypothesis that a combination of 1) autophagy induction, and 2) lysosomal dysfunction causing impaired autophagic flux, are both critical in the mechanism of alcoholic pancreatitis.
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