Abstract
A S L D A b st ra ct s recurrence during follow-up, while 5 patients in normal fibrinogen group (39 cases) developed tumor recurrence. Univariate analysis of factors revealed that age 5cm, tumor number>3, vascular invasion, serum alpha-fetoprotein (AFP) level≥400μg/ L, beyond Milan criteria, and fibrinogen level ≥2.71g/L were preoperative predictors of DFS and OS. Cox regression analysis showed that vascular invasion, tumor number>3, AFP≥400μg/L, and fibrinogen level≥2.71g/L were independent prognostic factors of poorer DFS, and vascular invasion, AFP≥400μg/L, and fibrinogen level≥2.71g/L were independent prognostic factors of poorer OS. Conclusion: Pretransplant elevated plasma fibrinogen level is associated with tumor recurrence and poor prognosis in patients after liver transplantation for HCC. Pretransplant plasma fibrinogen level may aid in the selection of patients that would most benefit from transplantation for HCC.
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