Sa1836 Active Metalloproteases Are Expressed Early on During the Esophagitis-Metaplasia Sequence and Are High in Barrett's Esophagus and Esophageal Adenocarcinoma

Abstract

G A A b st ra ct s 3 intensity levels (walking, moderate intensity and vigorous intensity) during the past 7 days. We categorized level of physical activity by low, moderate, or high using IPAQ definitions. We also estimated metabolic equivalent minutes per week (MET-min/wk) by weighting the reported minutes/week within each activity category by a MET energy expenditure estimate for each category of activity. We calculated odds ratios (OR) and 95% confidence intervals (95% CI) using multivariable logistic regression models adjusting for age, sex, race, GERD symptoms, H. pylori, BMI and high waist-to-hip ratio. Results: There were 323 cases with BE and 1849 controls (1347 from endoscopy and 502 from the primary care clinic) (Table 1). Most (68.8%) patients were in the lowest category of physical activity, 13.5% had moderate activity and 11.2% had high activity (6.5% were missing). BE cases were more likely to be in the high category physical activity category than controls (13.6% vs. 10.8% p=0.08). The overall average MET-min/week for walking were 909 for BE cases vs. 561 in controls (p=0.16); with similar findings for those with moderate activity (1094 METmin/week for BE cases vs. 755 for controls, p=0.175), and for vigorous activity (783.8 METmin/week for BE cases vs. 826.2 for controls, p=0.927). In multivariable logistic regression, physical activity was not significantly associated with BE (OR for high vs. low physical activity: 1.19 (95%CI: 0.8-1.73). In fact, BE patients were more likely to have high level of physical activity than PCP controls (OR: 2.1; 95% CI: 1.17-3.6). Conclusions: Recent amount and intensity of physical activity does not seem to be associated with significant changes in the risk of BE. Studies are required examine long term effects of physical activity.