Abstract
suppressed nuclear translocation of NFκB compared to non-invasive E. coli strains and LPS at 30 min post infection. However, unlike non-invasive E. coli strains, 13I and LF82 infection resulted in chronic activation of NF κB. Summary: CD-associated AIEC strains replicate within macrophages by initially suppressing NFκB activation. However, bacterial replication within macrophages induces chronic activation of NF κB, which correlates with increased TNF-α secretion from infected macrophages. Conclusion:Modulation of intracellular signaling pathways by invading CD-associated E. coli strains could contribute to an initial survival advantage and eventual chronic inflammation, as seen in CD.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
