Sa1780 Colorectal Adenoma and Cancer Prevalence in Hispanics: A Hospital Based Study

Abstract

Background: Among the race-ethnic groups in the US, African Americans have the highest colorectal cancer incidence and mortality whereas Hispanics have the lowest burden of the disease. Aim: To evaluate the prevalence of colorectal adenoma and carcinoma among inner city Hispanic population. Methods: We reviewed the reports of 1628 Hispanic patients who underwent colonoscopy at Howard University Hospital between 2000-2010. The mean age was 53.2 years, 64.2% were females. Advanced adenoma was defined as adenoma ≥ 1 cm in size or villous histology or high grade dysplasia or invasive cancer. Statistical analysis was performed using chi square statistics and t-test. Results: Among all patients, adenoma prevalence was 16.5% (n=268), advanced adenoma 2.3% (n=39), and colorectal cancer 0.4% (n=7). Hyperplastic polyps were seen in 6.6% of the cohort (n=107). Adenomas predominantly exhibited a proximal colonic distribution (53.7%, n=144); while hyperplastic polyps were mostly located in the distal colon (70%, n= 75). Among 11.7% (n=191) patients who underwent screening colonoscopy, the prevalence of colorectal lesions were 21.4% adenoma, 2.6% advanced adenoma; and 8.3% hyperplastic polyps. Conclusion: Our data showed low CRC prevalence among Hispanics; however colon adenoma prevalence was comparable to other ethnic and racial groups. Most colonic adenomas were located in the proximal colon, which supports the use of colonoscopy for CRC screening.