Sa1706 Cessation of Potentially Causative Medications Decreases Rebleeding Rate in Patients of Obscure GI Bleeding Without Definite Lesions on Capsule Endoscopy

Abstract

organ damage (OR 1.89, 95%CI 1.07 3.35), connective tissue disease (OR 2.09, 95%CI 1.1 4.0), Charlson comorbidity index (OR 1.11, 95%CI 1.02 1.20), and increasing transfusion requirements (3-9 units OR 1.72, 95%CI 1.13 2.63; 10 units OR 2.85, 95%CI 1.89 4.30) were significantly associated with positive findings on CE (all p 0.027). Following multivariable analysis, only increasing transfusion requirements (3-9 units OR 1.63, 95%CI 1.04 2.56; 10 units OR 2.63, 95%CI 1.62 4.26) and connective tissue disease (OR 2.18, 95%CI 1.09 4.31) remained significant (all p 0.033). Conclusions: While a number of trends were seen in the univariable analysis, only transfusion requirements and the presence of connective tissue disease were identified as significant factors associated with positive outcomes in the multivariable analysis. The low number of positive predictors limits our ability to utilize demographic and clinical factors as a tool to improve efficiency in selecting patients for CE.