Abstract
mice treated with cromolyn. Further, α-SMA, collagen I, fibronectin, TGF-β, MMPs, IL-6 and IL-10 were also significantly reduced in cromolyn-treated MDR2-/mice compared to MDR2-/control mice. Serum levels of HA and IL-6 were all increased in MDR2-/mice, but decreased after cromolyn treatment. In vitro, after co-culture with mast cells (containing stable levels of HA) there was increased cholangiocyte and HSC fibrotic marker expression as well as HA secretion. When cholangiocytes and HSCs were treated with mast cells lacking histamine (MC-HDC), these parameters decreased compared to basal-treatment.Conclusion: Our studies reveal that mast cell-derived histamine is contributor to HSC activation, liver inflammation and fibrosis. Modulation of mast cells may be an option for the treatment of chronic cholestatic disease and fibrotic injury.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
