Sa1624 Effect of Long-Term PPI Administration on NSAID-Induced Small Intestinal Lesions and Therapeutic Effect of Irsogladine, a Gastroprotective Drug, for Such Lesions in Healthy Volunteers

Abstract

Proton-pump inhibitors (PPIs) such as omeprazole are a standard treatment to prevent non-steroidal anti-inflammatory drugs (NSAIDs)-induced upper gastrointestinal mucosal injuries. However, it is unclear how small intestinal injuries are affected by long-term administration of PPIs and NSAIDs. Therefore, we investigated small intestinal lesions induced by 10 weeks' concomitant use of PPIs and NSAIDs in healthy volunteers. Moreover, we also examined the therapeutic efficacy of irsogladine for such lesions.