Sa1393 Efficacy and Safety of Carbon Dioxide Insufflation Versus Air Insufflation During Endoscopic Retrograde Cholangiopancreatography in Randomized Control Trials: Systematic Review and Meta Analysis

Abstract

Ambient air is the most commonly used insufflation gas in endoscopic procedures throughout the world; however, this procedure may cause pain and abdominal distension owing to the prolonged absorption of air in the gastrointestinal tract. Carbon dioxide (CO2) has been increasingly used in gastrointestinal endoscopy examinations because it is inflammable and is rapidly absorbed and excreted. Since the 1960s, endoscopic retrograde cholangiopancreatography (ERCP) has evolved rapidly and at present is considered the gold standard therapy for treatment of pathologies of the biliopancreatic system. For ERCP, the use of CO2 as the insufflation method is adequate because this procedure is complex and prolonged. The purpose of this systematic review and meta-analysis is to evaluate the efficacy and safety of the use of carbon dioxide compared with ambient air during ERCP examinations in randomized clinical trials.