Sa1354 The Manometric Profile of Cough and Throat Clearing in Reflux Monitoring Studies

Abstract

G A A b st ra ct s Center Transplant Immunology and Immunogenetics laboratory. Patients who tested negative for HLA DQ2/DQ8 were included in the study. Of the HLA DQ2/8 negative patients, those with gluten sensitivity defined as gastrointestinal and/or extraintestinal symptoms that improved exclusively on a gluten-free diet were identified. The frequencies of HLA DQ4, 5, 6, 7 and 9 in these patients were compared to frequencies in a large Caucasian population. Results:Of 194 patients who underwent HLADQ genetic testing, 54 patients were DQ2/DQ8 negative. Of these patients, 35 (29 female, 6 male; average age 40 + 13 years; predominantly Caucasian) were identified who had gluten sensitivity. Most patients (32/35) with gluten sensitivity had gastrointestinal symptoms. The most common gastrointestinal complaints were diarrhea (19 patients), gas/bloating (19 patients), and abdominal pain (13 patients). The most common extraintestinal symptoms were fatigue (9 patients) and weight loss (4 patients). The prevalence of HLA DQ alleles is shown in table 1. The most common alleles were HLA DQ6 and DQ7 that trended higher than reported in a large Caucasian population. Conclusion:HLA DQ6 and DQ7 were the most common alleles identified in patients with gluten sensitivity who lacked DQ2/8. While the frequency of DQ6 and DQ7 was higher than estimates in the general Caucasian population, a larger sample of gluten sensitive patients is needed to confirm this trend. HLA Prevalence in DQ2, DQ8 negative gluten sensitive patients (n=35) compared to Caucasian population controls