Sa1339 A Comparison of Psychological Associations With IBS and Ulcerative Colitis

Abstract

G A A b st ra ct s severity of gastrointestinal symptoms in FD and GvHD to identify potential differences in symptom severity and manifestation. Methods: Sixty-seven patients with aGvHD (I°-III°) and 45 patients with FD according to ROME III criteria were recruited. The following key symptoms were assessed utilizing the standardized Gastrointestinal Symptom Score: epigastric pain, cramps, fullness, early satiety, nausea and vomiting. AX and DEP were measured with the Hospital Anxiety and Depression Scale. Patients scoring 0-7 on each subscale were considered not having a psychological co-morbidity. Patients with 8-10 were categorized as probable (p) AX/DEP while patients scoring ≥11 were considered having a relevant (r) AX/ DEP. Analysis was performed by Spearman rank correlations and T test. Results: In GvHD pAX was found in 12/67, rAX in 6/67, pDEP in 4/67 and rDEP in 8/67. In FD pAX was observed in 12/45, rAX in 8/45, pDEP in 11/45 and rDEP in 6/45. Overall AX (p=0.54) and DEP (p=0.75) scores did not differ between FD and GvHD. AX in GvHD was correlated with severity of pain (r=.25, p=0.04), fullness (r=.43, p,0.001), satiety (r=.40, p=0.001), nausea (r=.36, p=0.003) and vomiting (r= .40, p=0.001). In FD AX correlated with pain (r=.44, p,0.028), fullness (r=.38, p,0.001), satiety (r=.23, p=0.03), vomiting (r=.32, p= 0.002). FD patients without AX showed significantly more severe cramps and nausea but less vomiting compared to GvHD without Ax. In FD patients with pAX and rAX pain was more prominent while vomiting was less evident compared to GvHD with pAX and rAX. DEP was associated with pain (r=.58, p,=0.001), cramps (r= .53, p,0.001), fullness (r= .64, p,0.001), satiety (r=.50, p,0.001), nausea (r=.43, p,0.001) and vomiting (r= .48, p,0.001) in GvHD but only with pain (r=.23, p ,0.001) in FD. FD patients with and without DEP were characterized by increased pain but decreased early satiety and less vomiting compared to respective GvHD groups. Conclusion: Psychological co-morbidity is closely linked to symptom severity in FD and organic GI disease. While patients with FD experience more pain, vomiting is more severe in GvHD. These differences may indicate different underlying pathophysiological mechanisms rather than psychologically driven factors.