Sa1203 Appendiceal Orifice Histology and Its Prognostic Significance in Patients With Ulcerative Colitis

Abstract

G A A b st ra ct s lesions confined to the ileocolonic anastomosis). Secondary outcome was to identify risk factors like Montreal classification, smoking behavior, previous resection(s), gender, family history of inflammatory bowel disease (IBD), surgery indication, type of anastomosis, ileum length resected and postoperative use of medication. Results In the 105 included patients, the overall endoscopic recurrence rate was 38.1%. The recurrence rate in patients who used postoperative biologics was 26.3%, 23.8% in patients who used immunomodulators and 51.9% in patients without postoperative medication. Only smoking the year before surgery (OR; 3.590, 95% CI 1.269-10.233, p=0.017) seemed to be a significant risk factor in the multivariate analysis for risk factors for endoscopic recurrence. Postoperative use of medication was a protective factor (not significant, but a trend OR; 0.381, 95% CI 0.142-1.018, p=0.054), which reduced the risk with 61.9%. Conclusion This is the first study that used the modified Rutgeerts score to evaluate endoscopic recurrence. In this retrospective multicenter cohort study, the endoscopic recurrence rate found was lower than in previous studies. Based on this study, special attention should be paid in the preoperative phase to patients with smoking habits. Postoperatively, an early start with immunomodulators or anti-tumor necrosis factor (TNF) therapy should be taken into consideration.