Abstract
of the segmental length among the striatedmuscle segment, proximal smoothmuscle segment, and distal smooth muscle segment. While the pressure volume of the proximal segment was significantly higher in the positive responders than the negative responders (900.4 ± 91.5 mmHg cm(-1) s(-1) vs. 780.5 ± 133.3 mmHg cm(-1) s(-1), p = 0.017), the pressure volume of the distal segment was significantly lower in the positive responders (1914.0 ± 159.8 mmHg cm(-1) s(-1)vs. 2140.5 ± 276.2 mmHg cm(-1) s(-1), p = 0.014). A prominent shifting in pressure volume to the distal segment was observed in the negative responders compared to the positive responders (segmental ratio of pressure volume (SRPV): 2.9 ± 0.5 vs. 2.1 ± 0.1, p < 0.001), and 2.39 was found to be the SRPV that best differentiated positive and negative responders (area under curve, 0.88; 95% confidence intervals, 0.71-0.97; p < 0.001). On the other hand, there was no significant difference between the groups in the segmental ratios regarding segmental length and maximal wave amplitude. CONCLUSIONS: A low SRPV was associated with a positive response to high-dose PPI treatment in patients with FCP.
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