Sa1140 The Clinical Features and Treatment Modality of Esophageal Neuroendocrine Tumors: Nationwide Multicenter Study in Korea

Abstract

G A A b st ra ct s test, rapid urease test or serology and subjects with positive results for at least one assay were classified as H. pylori-positive. Collected data were compared between the two groups. Results: 1007 Patients with PUD were identified, 172 (male 56.4%, mean age 63.2 years) in the period 2001/2002 and 835 (male 60.1%, mean age 65.6 years) in the period 20062010. The rate of endoscopic PUD increased from roughly 100 to 165 per year over the study period. Overall, 48.8% of patients had gastric ulcer, 41.8% had duodenal ulcer and 9.4% of patients had peptic ulcer in both localisations, with no differences between the two study groups. Data regarding the H. pylori infection and aspirin/NSAID intake could not be retrieved in 16.1% and 2.4% of patients, respectively. Overall, the prevalence of H. pylori infection decreased significantly from 52.8% to 38.4% (p=0.004) whereas the prevalence of aspirin/NSAID intake increased significantly from 37.5% to 47% (p=0.03) among patients with PUD. In both groups roughly 15% of PUD patients had both risk factors. The proportion of idiopathic peptic ulcers was 27% and 30% in group 1 and 2, respectively. Conclusions: The rate of endoscopic PUD in our institution increased over the study period. The prevalence of major aetiological factors for PUD changed substantially with a decrease of H. pyloripositive PUD and an increase of PUD associated with aspirin/NSAID intake.