Sa1053 Endoscopic Features of Mantle Cell Lymphoma With Involvement of the Digestive Tract

Abstract

Mantle Cell Lymphoma (MCL), is an aggressive subtype of non hodgkin lymphoma (NHL) of B phenotype. It represents 3% to 6% of the NHL with an anual incidence of 0.5 per 100,000 case series. It is most commonly diagnosed in advanced stages, with bone marrow and peripheral blood involvement, and generalized lymphadenopathy in 75%. Some patients have splenomegaly, hepatomegaly and extranodal disease such as lymphomatous polyposis of the colon; the MCL has a very aggressive behaviour with poor response to treatment. Gastrointesinal involvement at the moment of diagnosis is between 15-30%. Endoscopic findings vary from the most common manifestation called “lymphomatoid polyposis”, characterized by identification of multiple lymphoid polyps, mainly in tne small and large intestine to superficial ulcers and large tumors most common in valve ileocecal or normal appearing mucosa.