Abstract
Over the past decade technological advances have created entirely new opportunities for studying and understanding neural circuits and brain activities. Meanwhile the expansion of therapeutic scope of Deep Brain Stimulation has continuously happened together with the improvement in precision of stimulation and neurosurgical implantation techniques. The standard open-loop setup of high-frequency (HF) DBS utilizes permanent HF electrical pulse train, where electrical stimulation is administered continuously to the target areas irrespectively of the ongoing neural dynamics. Recent studies demonstrate that an adaptive, closed-loop DBS setup might be preferable over the open-loop setup. This presentation summarizes the technological advancements in closed-loop DBS system designs. We will discuss state-of-the-art implantable multielectrode technologies, requirements checklist for clinical practice, current issues, electronics designs as well as field potential and single unit activity based biomarkers with particular interest on Phase-amplitude coupling.
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