Abstract
The 7 Tesla (T) MRI is currently an investigational device and not in clinical use. Despite of its weak points, there are many advantages in it. Blood oxygenation-level dependent (BOLD) contrast is in main use for fMRI. This contrast becomes more than double at 7 T compared with 3 T, which is now mainly used. Higher contrast combined with higher SNR, 7 T affords us to investigate submillimeter changes, which can be applied to investigate intracortical layer-wise activity to investigate motion control and visual processing in schizophrenia and Parkinson’s disease. Moreover, resting-state fMRI of the whole brain can be conducted in a shorter time with less patient burden. At 7 T, the chemical shift of cerebral metabolites can be decomposed in detail as the resonance frequency increases, so measurement of GABA, Glutamate and others are easier with MR spectroscopy. As for structure measurements, there is a large trend to go quantitative. T1 and T2 star values are major indexes, and especially T2 star can be processed as quantitative susceptibility mapping (QSM) values. QSM is sensitive to iron, which accumulates at the amyloid plaque. By utilizing 7 T-MRI, it is expected to better elucidate pathophysiology of the brain.
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