Abstract
The peripartum period involves changes in neuroactive steroids (NAS) which may be associated with postpartum depression (PPD). We previously demonstrated that women at-risk for PPD, compared to healthy peripartum women, have altered NAS profiles suggesting a shift towards 5β- reduction of progesterone to pregnanolone. In this study, we measured plasma pregnane steroid precursors and NAS in healthy comparison peripartum women (HCPW) and women with PPD with/without anxiety.
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