Abstract
Sensory information from the gastrointestinal (GI) tract is transmitted centrally through vagal afferents that terminate within the nucleus of the tractus solitarius (NTS) and utilize glutamate as their principal neurotransmitter. Neurons of the NTS integrate this sensory information with inputs received from other brainstem and “higher” CNS center and relay the integrated signal to the adjacent dorsal motor nucleus of the vagus (DMV) using principally glutamate, GABA and norepinephrine as neurotransmitters.
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