Abstract
Meeting abstracts The development of immune-based strategies for cancer for solid cancers is challenged by the scarcity of T cells with high receptor avidity for tumor-specific antigens within the patient´s lymphocyte repertoire, and by the failure of tumor cells to present antigen to T cells.
Highlights
Convenient online submission Thorough peer review No space constraints or color figure charges Immediate publication on acceptance Inclusion in PubMed, CAS, Scopus and Google Scholar Research which is freely available for redistribution
The development of immune-based strategies for cancer for solid cancers is challenged by the scarcity of T cells with high receptor avidity for tumor-specific antigens within the patients lymphocyte repertoire, and by the failure of tumor cells to present antigen to T cells
Both obstacles can be bypassed by genetic modification of T cells with recombinant chimeric receptors (CARs) which redirect T cells towards a tumor surface antigen independent of antigen presentation
Summary
Rossig Journal for ImmunoTherapy of Cancer 2014, 2(Suppl 2):I17 http://www.immunotherapyofcancer.org/content/2/S2/I17 C Rossig From 1st Immunotherapy of Cancer Conference (ITOC1) Munich, Germany. The development of immune-based strategies for cancer for solid cancers is challenged by the scarcity of T cells with high receptor avidity for tumor-specific antigens within the patients lymphocyte repertoire, and by the failure of tumor cells to present antigen to T cells.
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