Abstract
Current antidepressants are safe and effective for the majority of patients, but the time until substantial improvement can take weeks or even months. Antidepressants of all classes act mostly unspecific, especially in higher doses, by globally enhancing monoaminergic neurotransmitter activity. This is contrasted by the heterogeneity of depression symptoms suggesting that specific antidepressant treatments personalized to the individual’s impairments should be superior to current treatment approaches.
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