Abstract
Limited data are available regarding the significance of biomarker in hypertrophic cardiomyopathy (HCM). We evaluated the relationship between several biomarkers and clinical/echocardiographic parameters. Results: 1. BNP: The plasma BNP levels were increased in patients with left ventricular (LV) outflow obstruction 30mmHg, maximum LV thickness 30mm and atrial fibrillation. Moreover, plasma BNP levels were significantly increased in those with adverse cardiovascular events. 2. Adiponectin: The plasma adiponectin levels were related to age, gender, body mass index, atrial fibrillation, %fractional shortening and maximum LV wall thickness, but were not related to LV outflow gradient. Multivariate analysis showed that %fractional shortening and maximum LV wall thickness were the independent echocardiographic predictors of the plasma adiponectin levels. 3. Matrix metalloproteinase (MMP)-2: The plasma MMP-2 levels in patients with LV systolic dysfunction were significantly higher than those in patients without systolic dysfunction. MMP-2 levels were positively related to LV end-diastolic dimension and left atrial dimension, and inversely related to maximum LV wall thickness and %fractional shortening. Conclusions: Each of these biomarkers is important for assessing the LV remodeling process. Measurement of multibiomarkers is useful to evaluate the disease severity and to predict the prognosis in HCM.
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