Abstract
Schizophrenia is conceptualized as a neurodevelopmental disorder, including a prodromal period during which biological vulnerability is expressed before the emergence of formal symptoms. Individuals at clinical high-risk for psychosis (CHR) are characterized by prodromal features resembling attenuated symptoms of psychosis and were previously found to show a blunted developmental trajectory for attaining theory of mind (ToM). Analysis of the NAPLS-II consortium sample was undertaken to determine whether ToM ability corresponds to neurophysiological metrics of brain maturation, and whether this relationship is altered in CHR.
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