Abstract
Nerve growth factor (NGF) is the paradigmatic target-derived neurotrophic factor on which the foundations of neurotrophic theory are based. Sympathetic neurons depend for survival on a supply of NGF synthesized by their targets and conveyed to their cell soma by retrograde axonal transport. The limiting supply of target-derived NGF not only governs the number of sympathetic neurons that survive during development, it also plays an essential role in promoting the growth and branching of the axon terminals of these neurons within their distal targets.
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