S3354 Impact of Multiple Sclerosis on the Outcomes of Patients Hospitalized With Inflammatory Bowel Disease

Abstract

Introduction: It has been reported that there is a possible association between inflammatory bowel disease (IBD) and multiple sclerosis (MS). Some studies suggest that there are familial links and shared genetic factors between two diseases, and MS course appears to be milder in patients with concomitant IBD. On the other hand, there is a lack of studies on how the outcomes of IBD are affected by MS. Thus, we aim to assess the outcomes of IBD in patients with concomitant MS. METHODS: Patients hospitalized with IBD from the National Inpatient Sample, Healthcare Cost and Utilization Project, Agency for Healthcare Research and Quality 2014 were selected. Diagnoses were identified by using ICD-9 CM codes. Outcomes of IBD were compared between the groups with and without MS. The outcomes of interest were inpatient mortality, length of stay, total hospital charge, and IBD complications including malnutrition, penetrating disease, stricturing disease/bowel obstruction, colectomy, and ileostomy. Chi-squared tests and independent t-tests were used to compare proportions and means respectively. Multivariate logistic regression analysis was performed to determine if MS is an independent predictor for the outcomes, adjusting for age, sex, race, and the Charlson Comorbidity Index. RESULTS: Among 34,374 patients with IBD identified in the study, 132 patients had MS. There were no statistically significant differences in inpatient mortality (0% vs 0.23%, p = 0.58), length of stay (4.4 days vs 4.6 days, p = 0.72), and total hospital charge ($33,730 vs $36,727, p = 0.48). After adjusting for age, sex, race, and the Charlson Comorbidity Index, there were no statistically significant differences in IBD complications including malnutrition (aOR 0.92, 95% CI: 0.38-2.27, p = 0.86), penetrating disease (aOR 0.43, 95% CI: 0.14-1.35, p = 0.15), stricturing disease/bowel obstruction (aOR 1.12, 95% CI: 0.70-1.79, p = 0.63), colectomy (aOR 0.63, 95% CI: 0.23-1.71, p = 0.36), and ileostomy (aOR 0.86, 95% CI: 0.32-2.33, p = 0.76). CONCLUSION: There were no differences in inpatient mortality, length of stay, total hospital charge, and IBD complications between groups with and without MS. Despite possible genetic links between IBD and MS, our study suggests that outcomes of IBD are not affected by the presence of MS.