S259 Effects of diabetes on renal cancer prognosis

Abstract

INTRODUCTION AND OBJECTIVES: Diabetes is a chronic disease characterized by impaired fasting blood glucose that leads to disturbances in various organs. In this study, we evaluate the relationship between tumor size and grade with diabetes in patients with renal cell carcinoma. METHODS: Between 2007-2013, 310 patients underwent radical nephrectomy for renal tumors and pathology reported renal cell carcinoma enrolled in the study. Fasting glucose levels and HbA1c levels compared with tumor size and Fuhrman grade in patients with and without a history of diabetes. The results were statistically analyzed. RESULTS: Diabetes was found in 98 patients. The mean age of the patients with and without diabetes mellitus, respectively 64.3 (4079) and 58.4 (31-87) years. In diabetes group we determined over 7 cm tumor size in 51% of patients and over fuhrman grade 3 tumor grade in 53% of patients. In non-diabetes group we determined over 7 cm tumor size in 38% of patients and over fuhrman grade 3 tumor grade in 28% of patients. The patients with diabetes compared to the patients without diabetes, tumor size and grade were detected significantly higher (p<0,05) in diabetes goup. CONCLUSIONS: Renal cancer remains more aggressive in patients with diabetes. In this study lifestyle and risk factors with diabetes regulation observed important for renal cancer patients. Multicenter studies are needed in larger series for more accurate results.