Abstract
The S-2,4,6-trimethoxybenzyl (Tmob) group can be introduced onto sulfhydryl functions form the corresponding alcohol, with acid catalysis, and is in turn removed rapidly by treatment with 30% trifluoroacetic acid-di-chloromethane in the presence of phenol, thioanisole, and water (5% each) or 6% trifluoroacetic acid-di-chloromethane in the presence of triethylsilane or triisopropylsilane (0.5%). The appropriate cysteine derivative was prepared and applied with other N α -Fmoc protected amino acids to the solid-phase syntheses of several model peptides
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