S234. Psychosis Risk is Associated With Decreased Resting-State Corticostriatal Connectivity With the Default Mode Network but Intact Connectivity With the Frontoparietal Network

Abstract

Psychosis is associated with aberrant salience and increased dopamine in the anterior dorsal striatum. Critically, the anterior dorsal striatum is connected to the default mode network (DMN) and, to a lesser extent, the frontoparietal network (FPN). The DMN is involved in self-relevance processing, suggesting that psychosis might be associated with abnormal connectivity between the striatum and the DMN. However, no previous study has directly examined striatal to DMN or FPN connectivity in psychosis risk.