S21 Hospital Outcomes in Depression and IBD: A Population Based Study

Abstract

Background: Although there are limited studies, patients with depression are more likely to be diagnosed with IBD. However, the effect of depression on mortality and morbidity for IBD patients has not been well studied. The aim of our study was to examine the impact of depression on the outcomes of patients with IBD. Methods: The Nationwide Inpatient Sample (NIS) database encompasses approximately 7 million inpatient hospitalizations annually in the United States. Data were extracted from the National Inpatient Sample (NIS) Database for the years 2015-2019. Patients aged 18 years and above with diagnoses of IBD and depression were identified using ICD codes. Multivariate regression analysis was used to estimate the odds ratios of in-hospital mortality, the average length of hospital stay (LOS), and hospital charges using STATA 17. Multivariate logistic and linear regression analysis was used accordingly to adjust for confounders. Results: We identified 1,198,839 patients with IBD of which 191,175 patients were matched to those with anxiety. Average age was 54.88 years. There was a significant decrease in inpatient mortality (OR 0.68, CI 0.62-0.76, P < 0.0001) and total cost of hospitalization (-$2,573.35, CI -3,678.41 - -1,468.29, P < 0.0001), but hospital length of stay increased (0.24 days, CI 0.16-0.31, P < 0.0001) between patients with IBD with cannabis use when compared to IBD patients without cannabis use. Conclusion(s): Our results show that patients with depression and IBD had decreased mortality and total hospital charges compared to those with IBD that were statistically significant. This may be due to the increased screening and follow up for patients with both IBD and depression. In the future, team-based management of IBD with both gastroenterologists and psychiatrists may further improve outcomes for this patient population. Identification and management of depression in the IBD population can improve healthcare outcomes and quality of life.