S2003 Serum Vitamin D Level and Disease Activity in Pediatric Inflammatory Bowel Disease

Abstract

presence of disabling chronic symptoms, need for immunosuppressive therapy and intestinal resection or perianal surgery. (b) Liege Hospital (Belgium) definition including at least one of the following criteria: development of a complex perianal disease, any colonic resection, more than one small-bowel resection or a definite stoma. (c) a new definition that we proposed including nutritional impairment defined by a BMI or weight or height less than 2SD Z scores and at least one intestinal resection or two perianal surgeries. RESULTS: According to definition (a), the rate of PO was 76%. Independent predictors at diagnosis were L2L3 (Montreal classification) (OR: 3.74 [1.71-8.22]) and nutritional impairment (OR: 2.47 [1.26-4.85]). According to definition (b), the rate of PO was 34% and the only predictive factor was B2B3 behaviour at diagnosis (OR: 3.26[1.77-6.02]). According to definition (c), the rate of PO was 15% and predictors were B2B3 behaviour (OR: 3.42 [1.179.95]), nutritional impairment at diagnosis (OR: 5.35 [1.89-15.16]), and an age between 14 and 17 years at diagnosis (OR: 4.07 [1.44-11.49]). Bootstrap validation is ongoing. CONCLUSION: Using a new descriminant definition, 15% of children developped PO within 5 years after diagnosis. Nutritional impairment and stricturing or penetrating behaviour at diagnosis were predictors of PO as well as an age between 14 and 17 years at diagnosis. If validated, these predictors may be useful to select patients in whom early intensive therapy should be considered.