Abstract
Paroxysmal depolarization shift (PDS) was extensively studied in animal models of acute and subacut epilepsy. Based on the observation that PDS occurred between behavioral seizures it had been complemented by interictal discharges, that can be recorded in humans in the seizure onset zone (SOZ) and around. PDS is characterized by excessive discharge of large number of neurons within a certain area of the cortex. Studying human SOZ with microelectrodes revealed that selective or no neuronal firing increase happen during IIDs. In this lecture we demonstrate interictal and ictal neuronal discharge patterns in humans and compare to PDS recordings from animals. Based on similarities and discrepancies we try to conclude how neuronal hyperexcitability can be interpreted in human chronic epilepsy compared to our understanding from animal models.
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