S1943 Fecal Methylated Gene Markers for the Early Detection of Dysplasia and Cancer of the Pouch in Ulcerative Colitis (UC) Patients With Restorative Proctocolecomy (RC) and Ileal Pouch-Anal Anastomosis (IPAA)

Abstract

G A A b st ra ct s confounding variables. Results: Colonoscopy was performed in 340/401 (85%), mean age 64 years (range 21-90 years), 166 (49%) were male. The median waiting time for colonoscopy was 23 days (range 6-47 days). The cecum was reached in 297/340 (87%) of cases. Forty cancers (11,6%) were diagnosed, 24 were located in the colon and 16 in the rectum. Male sex (OR 2.12, 95% CI 1.06-4.22, p< 0.05) and rectal bleeding (OR 3.31, 95% CI 1.596.87, p = 0.001) were independent predictors of CRC. Rectal bleeding had an independent predictive value for male rectal cancer (OR 5.28 CI 1,13-24,65, p <0.02), whereas iron deficiency anemia was a good predictor of proximal CRC (OR 3.57; 95% CI 1.87-8.14, p <0.0001). None of the 68/340 (20%) patients presenting only with CBH had CRC. Conclusions: This study confirms that rectal bleeding and macrocytic anemia are good predictors of CRC, especially in man. However, CBH, if is not accompanied by other alarm symptom, does not predicts CRC. This indication represents a significant amount of unnecessary colonoscopies for suspected CRC and should be considered to be excluded from the current list of indications for prompt referral colonoscopy.