S187 Influence of repetitive transcranial magnetic stimulation on cognitive and motor performance in parkinson’s disease patients

Abstract

Objective To assess the influence of combined repetitive transcranial magnetic stimulation (rTMS) with tradmill training on cognitive and motor performance in Parkinson’s disease (PD) patients. Methods Forty-five PD male and female patients participated in this study. Age ranged from 55 to 70 years. The patients were assigned into three equal groups; two control groups (GIG and the second control group (GII) treated by the same program in addition to aerobic exercise on treadmill for 20 min. The study group (GIII) received (5 Hz) rTMS followed by the same program as (GII). The treatment program was conducted three sessions per week, for four weeks; the duration of each session ranged from 40 to 55 min. Biodex balance system, key board tapping and two-dimensional motion analysis were used to assess balance, bradykinesia and gait; respectively. PD cognitive rating scale and auditory event related potential (P300) were used to evaluate cognitive functions pre- and post-treatment. Results Pre-treatment there was a non-significant difference in the mean values of all variables in the three groups. Post-treatment there was a significant improvement in spatiotemporal gait parameters and bradykinesia in the three groups with more improvement in (GIII) ( P 0.05 ). Improvement in balance and cognitive functions was observed only in (GII&GIII). There was a significant difference in variables of dynamic balance indices between both groups. Conclusion Treadmill training combined with rTMS has a positive effect on both cognitive and motor performance in PD patient.