Abstract
G A A b st ra ct s 1). This profile was similar to the spinal thoracic dorsal root ganglia (DRG) TRPV1-positive nociceptors innervating the esophagus (also derived from neural crest). In stark contrast, the putative placodes-derived JNG nociceptors (TRPV1+/P2X2+) lacked PPTA, GFRα3 and TrkA , but expressed TrkB. We conclude that both the neural crestand placodes-derived vagal nociceptive neurons innervate the mouse esophagus. The phenotype of neural crestderived nociceptors in the vagal and spinal (DRG) pathways is similar, but distinct from the phenotype of the vagal placodes-derived nociceptors. Supported by DK074480 and MZdSR 2007/54UK15. Table 1. Phenotypes of the TRPV1-positive neurons retrogradely labeled from the mouse esophagus
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