Abstract
BackgroundSeveral studies have produced a large body of evidence for white matter abnormalities related to schizophrenia. The literature has yet to achieve a state of consistency and reproducibility, and reported low integrity of white matter tracts vary between studies. Whole brain image study with large sample size is needed to address this issue. We investigated white matter integrity in connections between regions of interests (ROI) in the same hemisphere in patients with schizophrenia and healthy controls with public neuroimaging data from SchizConnect (http://schizconnect.org).MethodsA final data set was consisted of 129 healthy controls and 122 schizophrenia patients. For each diffusion weighted image (DWI), a two-tensor full-brain tractography was performed, and DWI images were parcellated by processing and registering the T1 images with FreeSurfer and the Advanced Normalization Tools. We extracted a total of 36 tracts in the both hemisphere connecting ROIs in the same hemisphere with white matter query language. We compared means of diffusion measures between patients and controls, and evaluated correlations with Letter-number sequencing (LNS) test, Vocabulary test, letter fluency test, category fluency test, and trails A of the Trail Making Test (TMT). The Benjamini-Hochberg procedure with false discovery rate (FDR) of 0.05 was used to correct for multiple comparisons.ResultsWe found a significant RD and TR increase of the left thalamo-occipital tracts and the right uncinate fascicle (UF), and a significant RD increase of the right middle longitudinal fascicle (MDLF), and the right superior longitudinal fascicle (SLF) ii in schizophrenia. There were correlations between the TR in the left thalamo-occipital tracts and letter fluency test, and the RD in the right SLF ii and LNS test, which did not survive after correction for multiple comparisons.DiscussionThese results indicate widespread abnormalities of white matter fiber tracts in schizophrenia, contributing to the pathophysiology of schizophrenia.
Highlights
The amygdala volume is reduced already in the first episode of psychosis
Since the amygdala is comprised of separate subnuclei with distinct anatomy and function we wanted to study whether these effects are present in some subnuclei more than others in first episode of psychosis
We studied amygdala subnuclei volumes in 68 first-episode psychosis (FEP) patients and 65 healthy controls randomly selected from the general population
Summary
S391 targeting mitochondrial 18 kDa translocator protein (TSPO) to determine microglial activation and a T1 MRI scan to study structural brain characteristics including brain volume, cortical thickness, and hippocampal shape. Results: Using a vertex-wise analysis, we observed a significant microglial activation-by-diagnostic group interaction in morphological measures across the left hippocampus. We observed associations between microglial activation and outward and inward morphological alterations in the dorsal and ventro-medial portions of the left hippocampus, respectively. These associations were only observed in first-episode psychosis group. Discussion: Our results, for the first time, suggest a connection between microglial activation and morphological alterations in hippocampus of first-episode psychosis. AMYGDALA SUBNUCLEI VOLUMES IN FIRST-EPISODE PSYCHOSIS: ASSOCIATION WITH CHILDHOOD ADVERSITY. Reetta-Liina Armio*,1, Heikki Laurikainen, Raimo Salokangas, Lauri Tuominen, Jarmo Hietala1 1University of Turku; 2Harvard University, University of Turku
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