Abstract
BackgroundThe ZNF804A gene and cannabis use are risk factors for psychosis, both of which have also been associated with schizotypic traits. This study aimed to test whether ZNF804A (rs1344706) modulates the relation between cannabis use and schizotypy levels in a general population sample.MethodsThe sample consisted of 389 Spanish non-clinical subjects (43% males, mean age=21.1(2.19)). Schizotypy was evaluated with the three factors of the Schizotypal Personality Questionnaire-Brief (SPQ-B): Cognitive-Perceptual (CP), Interpersonal (I) and Disorganized (D). Subjects were classified as cannabis users or non-users. Multiple linear regressions were conducted to test the effect of genetic and environment factors and their interaction on SPQ-B scores. Sex and anxiety scores (evaluated with SCL) were included as covariates.ResultsThe analyses showed a significant linear relationship between the ZNF804A and SPQ-I: homozygotes AA showed higher scores (p=0.001). An interaction between cannabis use and rs1344706 on SPQ-CP was observed: among individuals AA, cannabis users presented higher scores than non-users, while among individuals CC, cannabis users presented lower scores compared to non-users (p=0.005).DiscussionThese results add evidence on that the ZNF804A modulates schizotypy and suggest that schizotypy levels are influenced by an interaction between the exposure to cannabis and the ZNF804A genotype.
Highlights
The ZNF804A gene and cannabis use are risk factors for psychosis, both of which have been associated with schizotypic traits
This study aims to investigate whether auditory P300 predict prognosis in patients with first episode psychosis (FEP) during 1-year of follow-up period
Twenty-four patients with FEP were examined with auditory P300 at baseline, and their clinical status were re-assessed after 1 year
Summary
S17. ZNF804A GENE AND CANNABIS USE: INTERACTION ON THE RISK FOR PSYCHOSIS IN A NON-CLINICAL SAMPLE Jordi Soler Garcia*,1, Barbara Arias2, Jorge Moya3, Manuel Ignacio Ibañez4, Generós Ortet4, Lourdes Fañanás2, Mar Fatjó-Vilas2 1University of Barcelona, Biomedicine Institute of the University of Barcelona (IBUB); 2University of Barcelona, Biomedicine Institute of the University of Barcelona (IBUB), Centre for Biomedical Research Network on Mental Health (CIBERSAM); 3University of Lleida, Centre for Biomedical Research Network on Mental Health (CIBERSAM); 4Universitat Jaume I, Centre for Biomedical Research Network on Mental Health (CIBERSAM)
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