Abstract
Investigation into the pathological mechanisms underlying postpartum depression (PPD) and preclinical testing of potential treatments for PPD has been hindered by the lack of animal models of such a complex disorder. Our laboratory has characterized two preclinical mouse models of PPD, mice lacking δ subunit-containing GABAA receptors (GABAARs) (Gabrd-/- mice), and mice lacking the K+/Cl- co-transporter, KCC2, specifically in corticotropin-releasing hormone (CRH) neurons (KCC2/Crh mice). These studies established two unique mouse models which serve as useful tools for testing novel therapeutic compounds.
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