Abstract
loss of colonic crypts with inflammatory mononuclear cell infiltration. In contrast, WT colons had well preserved colonic architecture with inflammatory cell infiltration. Conclusions: We have shown that IAP-KO mice were unable to recover from DSS-induced chronic colitis compared with wild-type. The lack of weight-loss may be due to the enhanced absorption of dietary fat known to occur in the IAP-KO mice. Our results suggest that the gut mucosal defense factor, IAP, may play an important role in protecting the host against effects of intestinal injury/inflammation.
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