S157. Neurocognitive Performance Predicts Treatment Outcome With Cognitive Behavioral Therapy for Major Depressive Disorder

Abstract

Cognitive behavioral therapy (CBT) is an effective, widely-used treatment for depression, but predictors of its antidepressant benefit are lacking. While pretreatment neurocognitive functioning has been shown to predict pharmacological antidepressant treatment outcome (e.g., Bruder et al. 2014), research on neurocognitive functioning as a predictor of CBT treatment outcome is less extensive. The current study examined the contribution of baseline neuropsychological functioning to the prediction of antidepressant outcome with CBT for Major Depressive Disorder (MDD). We hypothesized that depressed participants who were more neurocognitively intact would respond better to the structured approach of CBT.