S148. Diagnostic and predictive value of central motor conduction time (CMCT) for acute ischemic stroke patients

Abstract

Introduction Central motor conduction time (CMCT) is the time taken for neural impulses to travel through the central nervous system on their way to the target muscles. When the motor cortex is stimulated with transcranial magnetic stimulation (TMS), CMCT is calculated by subtracting the peripheral conduction time from the motor evoked potential latency elicited by motor cortical TMS. As prolongation of CMCT, which suggests dysfunction of corticospinal tract, in certain clinical conditions, it is of diagnostic value and it can also be used as a prognostic marker in some of neurological conditions, such as myelopathy and multiple sclerosis (MS). The pathophysiology of pyramidal dysfunction in stroke is quite different from that in myelopathy because the pyramidal weakness of stroke patients may improve while the original lesions remain unchanged. The aim of this study is to investigate the role of CMCT for acute ischemic stroke patients and discuss which clinical and MRI characteristics correlate with the prolongation of CMCT. Methods Totally 94 patients with acute ischemic stroke (age: 67.13 ± 10.73 y/o; M%: 69.15%) were enrolled in this study. They all received evaluation of stroke risk factors, clinical course record (eg, TIA, Clinical Progression), neurologic examination (include muscle power on MRC score, NIHSS and mRS on admission), CMCT exam (CMCT(+) indicates CMCT prolongation), cranial MRI exam, data analysis and then were classified as clinical“New Stroke”,“Ever Stroke”,“Any lesions on MRI”,“New Pyramidal lesions on MRI”, and“Ever Pyramidal lesions on MRI”groups. Results The CMCT (+) group has significantly more cases in the “New Stroke”, “TIA”, “Progression”, “Any Lesions”, “New Pyramidal lesions on MRI”, “Ever Pyramidal lesions on MRI” and “MP Conclusion CMCT is both of diagnostic value of acute ischemic stroke with new pyramidal lesions and predictive value of stroke progression.