S146 Microvascular endothelial cell apoptosis and dysregulation of Vascular Endothelial Growth Factor Receptor 2 (VEGF-R2) in response to cigarette smoke. New insights into the pathogenesis of emphysema

Abstract

Microvascular injury may be a primary mechanism in the pathogenesis of emphysema. Rats treated with a VEGF-R2 antagonist develop emphysema that is caspase-3 dependent. Additionally, patients with emphysema have reduced...