S1429 Outcomes of Pyogenic Liver Abscess (PLA) on Mortality and Hospitalization Cost Amongst Patients With and Without Cirrhosis: 4-Year Retrospective Study Using National Inpatient Sample (2016 – 2019)

Abstract

Introduction: Liver abscesses are the most common type of intra-abdominal abscess. Risk factors for developing pyogenic liver abscess include diabetes mellitus, chronic hepatobiliary disease. Limited data is available comparing the clinical outcomes in cirrhotic patients who develop pyogenic liver abscess. Methods: Using National Inpatient Sample databases from 2016 to 2019, we identified patients presenting with pyogenic liver abscess, the population were then divided based on the presence and absence of cirrhosis using appropriate ICD-10-CM/PCS codes. STATA 17.0 software was used for the analysis. Pearson’s Chi-Square test was used to analyze categorical variable, whereas the student t-test was used to analyze continuous variables. Univariate and multivariate logistic regression was used to adjust for potential confounders. Primary outcome was in hospital mortality due to Pyogenic liver abscess in patients with cirrhosis vs without cirrhosis. Results: Amongst total of 19,830 patients admitted with pyogenic liver abscess, 1,770 patients had cirrhosis and 18,060 patients did not. Both groups consisted predominantly of white male patients. Mean LOS was 9.47+- 8.17 days in cirrhotic group and 7.18 +- 6.08 in non-cirrhotic group. This difference was statistically significant. Mean total hospitalization charges were $26,845 and $18,347 in the cirrhotic and non-cirrhotic groups respectively. There was no difference in the in-hospital mortality between the groups. (Table) Conclusion: Compared to those without cirrhosis, patients with cirrhosis who are admitted with pyogenic liver abscess showed had higher hospital resource utilization in terms of lenght of stay and charges. Though Mortality was higher in PLA with cirrhosis group, the result was not statistically significant Table 1. - In-patient outcome comparison of cirrhotic patients presenting with pyogenic liver abscess PLA with cirrhosis, N(%) PLA without Cirrhosis, N(%) P value Total 1770(8.92) 18060(91.70) Mean age (Years) 60.93±14.23 61.30±15.59 Female(%) 724(40.9) 7404(41) 0.946 Primary Outcome Odds Ratio 95% Confidence Interval P value Mortality(%) 1.673 0.213-13.088 0.624 Secondary Outcomes Mean Mean P Value Lenght of stay(days) 9.47+/-8.17 7.18+/-6.08 < 0.001 Charges (US$) 26845 18347 < 0.001