S1396 Glycosylated Hemoglobin Relation With Gastric Emptying Study in Gastroparesis

Abstract

Introduction: Gastroparesis is a debilitating disorder which includes several upper abdominal symptoms and documented slow gastric emptying (AJG 2013; 108:18). Past studies have shown heterogenous results of correlations between the glycemic control and the gastric emptying study. We aim to study the association of glycosylated hemoglobin (HbA1c) with gastric emptying. Methods: We performed retrospective review of the patients diagnosed with diabetic gastroparesis between September 30th, 2009 and January 31st, 2020. The 99mTc sulfur labeled food study was used to diagnose gastroparesis. Gastric emptying of < 90% for solids at 240 minutes and < 95% for liquids at 60 minutes were identified as delayed gastric emptying. We examined the relationship of HbA1c levels with the rate of gastric emptying examined by various gastric emptying test. The cohort was further divided into HbA1c levels < 7% (good diabetes control), 7-9% (fair diabetes control) and >9% (poor diabetes control). Results: There were 129 patients (mean age 51.1 ± 14.2 years, 61.8% female, 64.1% white) with diabetic gastroparesis. The mean HbA1c level was 8.3 ± 2.2 %. We observed that the HbA1c levels were not associated with level of gastric emptying with either solid (r=-0.12, p=0.28) or liquid study (r=-0.15, p=0.17). The mean gastric emptying was 74.3 ± 20.9% for solids and 67.9 ± 23.6 % for liquids with good glycemic control, 70.8 ± 20.1 % for solids and 52.3 ± 31.1 % for liquids in patients with fair diabetes control and 64.4 ± 26.7 % for solids and 52.9 ± 31 % for liquids in the patients with poorly controlled diabetes mellitus. The level of glycemic control did not predict the percentage of solid gastric emptying (p=0.29) whereas there was trend towards inverse relation with liquids (p=0.09). Conclusion: There is no correlation between the HbA1c levels and gastric emptying time. The level of diabetes mellitus control does not predict the severity of gastroparesis at the time of diagnosis.Figure 1.: A. Correlation of HbA1c levels with liquid gastric emptying at 60 minutes, B. Correlation of HbA1c levels with solid gastric emptying at 240 minutes, C. Glycemic control category and gastric emptying studies (240 min solid and 60 min liquid).Table 1.: Patients’ characteristic and comparison of diabetic gastroparesis with diabetic non-gastroparesis.