S1319: A novel β 2-adrenoceptor agonist from a marine sponge Dysidea sp.

Abstract

In the course of screening of potential leads for β 2-receptor agonists, we found a novel β 2-adrenoceptor selective agonist, S 1319, from a marine sponge Dysidea sp. The active compound was isolated and structurally characterized as 4-hydroxy-7-[1-(1-hydroxy-2-methylamino)ethyl]-1,3-benzothiazole-2(3 H)-one, a new member of the β 2-adrenoceptor agonist. This is the first example of a sponge-derived β 2-adrenoceptor agonist.