Abstract
It is well known that the mismatch negativity (MMN) has multiple generators: one in the temporal lobe and another in the frontal lobe. To investigate the effect of an epileptic focus on MMN, we compared the MMN of patients with temporal lobe epilepsy (TLE) with various seizure frequencies with the MMN of healthy controls. The MMN was consistently altered in TLE with the use of multiple types of stimuli. The MMN was enhanced at fronto-central sites and reduced at mastoid sites. TLE patients with lower seizure frequencies showed larger MMN amplitudes for deviant responses to phonetic stimulation at Fz. Taken together, our findings show that epileptic foci in the temporal lobe affect frontal and temporal function differently. The diminished MMN at mastoid sites may reflect dysfunction of the temporal lobe in TLE. In contrast, the enhanced MMN at fronto-central sites may reflect an increase in hyperexcitability or hypersynchronous activity. The results are consistent with previous reports of changes in frontal lobe function in TLE. In addition, we present a case of longitudinal changes of the MMN in TLE.
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