S12. Clinical and neurophysiological profile of adult epilepsy population of Bishkek

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Introduction Aim of the study is to study clinical and neurophysiological profiles of epilepsy patients of Oktober district of Bishkek. Methods The study involved 430 patients with epilepsy during 2014–2016y from clinical neurology department of City Hospital and Family Medicine Centers of Oktober district of Bishkek. Results When evaluating EEG data, it was found that 153 (35.6%) patients had focal epileptic activity, while 107 (24.9%) had generalized. At the same time, 170 (39.5%) patients suffering from epilepsy performing EEG did not reveal any epileptic activity interictallly. In those patients who had epileptic foci in the routine EEG, they were most often recorded in the frontal (14.9% of the total sample size) and in the parieto-occipital region (9.1% of the total sample size). In the analysis of MRI, the lesions of the frontal, temporal and parietal lobes were simultaneously the most frequent (50 cases or 11.6%), moreover, changes were often detected in the medial divisions of the temporal lobe (20 cases or 4.7%). In 126 cases (29.3%) no changes were detected on the MRI. In 57 (13.2%) cases, neuroimaging was not performed. In the group of patients (153) with the focus established according to the EEG data, the greatest correlation (kA = 0.21) between the epileptic focus and the pathological focus on MRI images coincided for the frontal and frontal parietal areas. In the differential analysis of the structure of seizures, depending on the localization of epileptic focus on the EEG, partial seizures prevailed in various combinations (54.5%) in patients with temporo-parietal focus, in patients with all other areas EEG focuses most often were observed primary GTCS. Conclusion The above data clearly demonstrate that, despite the fact that MRI is an obligatory method of investigation in patients with epilepsy, in reality for citizens of Kyrgyzstan, MRI is often inaccessible, is only in private clinics and is costly. Therefore, it is necessary to equip state hospitals with modern MRI devices, which should be one of the priority directions for the development of domestic epileptology. Taking into account that in 39.5% of cases during routine EEG in the surveyed population, it was not possible to detect focal activity for the purpose of timely diagnosis and adequate therapy of AED in the absence of focal activity according to routine EEG data, it is necessary to perform 3 or 6 h video EEG monitoring.